A turn-on probe for detecting antituberculotic drug-induced liver injury in mice via NIR-II fluorescence/optoacoustic imaging.

Longqi ChenJunjie ChenYichang FangFang Zeng Shuizhu Wu

Published in: Chemical communications (Cambridge, England) (2021)

A turn-on optoacoustic and NIR-II fluorescent probe for imaging antituberculotic drug-induced liver injury has been developed. Probe TC-H2O2 responds to hepatic H2O2, thus releasing chromophore TC-NN, which displays prominent NIR-II fluorescence and optoacoustic signals for diagnosing liver injury.

Keyphrases

fluorescent probe
living cells
liver injury
drug induced
high resolution
single molecule
adverse drug
energy transfer
drug delivery
type diabetes
mass spectrometry
photodynamic therapy
drug release