Interferon-γ enhances the immunosuppressive ability of canine bone marrow-derived mesenchymal stem cells by activating the TLR3-dependent IDO/kynurenine pathway.
Jiaqiang DengDanting LiXiaoya HuangWeiyao LiFangfang ZhaoCongwei GuLiuhong ShenSuizhong CaoZhihua RenZhicai ZuoJunliang DengShu-Min YuPublished in: Molecular biology reports (2022)
Our findings substantiate that IFN-γ stimulation can enhance the immunomodulatory properties of cBMSCs by promoting TLR3-dependent activation of the IDO/kynurenine pathway, increasing the secretion of immunoregulatory molecules and strengthening interactions with T lymphocytes, which may provide a meaningful strategy for the clinical application of cBMSCs in immune-related diseases.