DNA methylation is associated with airflow obstruction in patients living with HIV.
Ana I Hernandez CorderoChen Xi YangMaen ObeidatJulia YangJulie MacIsaacLisa McEwenDavid LinMichael KoborRichard NovakFleur HudsonHartwig KlinkerNila DharanSf Paul ManDon D SinKen M KunisakiJanice Leungnull nullPublished in: Thorax (2020)
A large number of DMPs were associated with airflow obstruction and lung function in a unique cohort of PLWH. Airflow obstruction in even relatively young PLWH is associated with global hypomethylation, suggesting advanced epigenetic ageing compared with those with normal lung function. The disturbance of the epigenetic regulation of key genes not previously identified in non-HIV COPD cohorts could explain the unique risk of COPD in PLWH.
Keyphrases
- lung function
- chronic obstructive pulmonary disease
- dna methylation
- cystic fibrosis
- air pollution
- end stage renal disease
- genome wide
- gene expression
- newly diagnosed
- ejection fraction
- chronic kidney disease
- antiretroviral therapy
- hiv infected
- hepatitis c virus
- human immunodeficiency virus
- peritoneal dialysis
- prognostic factors
- hiv testing
- hiv aids
- men who have sex with men
- transcription factor