Combination therapy with chitosan/siRNA nanoplexes targeting PDGF-D and PDGFR-β reveals anticancer effect in breast cancer.

Emine SalvaSuna ÖzbaşSaadet AlanNaziye ÖzkanCeyda Ekentok-AtıcıLevent KabasakalJülide Akbuğa

Published in: The journal of gene medicine (2022)

According to the results obtained, we evaluated the effect of PDGF-D and PDGFR-β on breast tumor development and showed that RNAi-mediated inhibition of this pathway formulated with chitosan nanoplexes can be considered as a new breast cancer therapy strategy.

Keyphrases

cancer therapy
drug delivery
combination therapy
smooth muscle
vascular smooth muscle cells
hyaluronic acid
wound healing
young adults