Doxorubicin Delivered via ApoE-Directed Reduction-Sensitive Polymersomes Potently Inhibit Orthotopic Human Glioblastoma Xenografts in Nude Mice.

Jia OuyangYu JiangChao Deng Zhiyuan ZhongQing Lan

Published in: International journal of nanomedicine (2021)

This ApoE-docked multifunctional polymersomal doxorubicin induces potent and safe chemotherapy of orthotopic U-87 MG model in nude mice offering an alternative treatment modality for GBM.

Keyphrases

drug delivery
cancer therapy
high fat diet induced
cognitive decline
endothelial cells
high fat diet
wild type
insulin resistance
squamous cell carcinoma
metabolic syndrome
radiation therapy
type diabetes
adipose tissue
induced pluripotent stem cells
anti inflammatory
skeletal muscle
chemotherapy induced