Combination of exercise and calorie restriction improves the development of obesity-related type 2 diabetes mellitus in KKAy mice.
Takumi SugimotoRan UchitomiTakumi OnishiYasutomi KameiPublished in: Bioscience, biotechnology, and biochemistry (2022)
We observed that exercise and calorie restriction reduced the body weight and blood glucose levels, concurrently improving insulin resistance and glucose tolerance in obese/diabetic model KKAy mice. Analysis of gene expression in the skeletal muscle showed enhanced mRNA levels of GLUT4 (glucose uptake), ATGL (lipolytic enzyme), and slow-twitch myosin heavy chain, which may contribute to the antiobesity and antidiabetic effects.
Keyphrases
- insulin resistance
- high fat diet induced
- blood glucose
- glycemic control
- weight loss
- skeletal muscle
- type diabetes
- body weight
- adipose tissue
- metabolic syndrome
- gene expression
- high intensity
- high fat diet
- polycystic ovary syndrome
- bariatric surgery
- binding protein
- physical activity
- dna methylation
- blood pressure
- resistance training
- weight gain
- cardiovascular risk factors
- wild type
- drug induced