Structure-Based Drug Design for Targeting IRE1: An in Silico Approach for Treatment of Cancer.

Alireza PoustforooshSanaz FaramarzMohammad Hadi NematollahiMehdi MahmoodiMahdiyeh Azadpour

Published in: Drug research (2023)

Our results revealed that designed compound 17 could inhibit IRE1 activity. Therefore, this designed compound is a remarkable inhibitor of IRE1 and introduces a promising therapeutic strategy for cancer treatment.

Keyphrases

endoplasmic reticulum stress
papillary thyroid
squamous cell
molecular docking
single cell
combination therapy
drug delivery
drug induced
smoking cessation