Klotho and SIRT1 changes from pre-diabetes to diabetes and pre-hypertension to hypertension.
Mahboobeh Yeganeh-HajahmadiHamid NajafipourFarzaneh RostamzadehAhmad Naghibzadeh-TahamiPublished in: Diabetology & metabolic syndrome (2021)
The serum levels of the anti-aging proteins Klotho and SIRT1 increases or reduces at the onset of the disease, as a compensatory mechanism, but as the disease progresses their level recovers.