Selective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Attenuates High-Fat Diet-Induced Hepatic Steatosis in Mice.

Huashan LiJianying ShengJing WangHaiting GaoJing YuGuoxian DingNing DingWei-Qi HeJuanmin Zha

Published in: Drug design, development and therapy (2021)

Our study shows that moderate inhibition of 11β-HSD1 by BVT.2733 reduces FFAs and corticosterone synthesis in fatty tissues, thereby attenuates the delivery of corticosterone and FFAs to the liver. Collectively, this prevents high-fat diet-induced hepatic steatosis.

Keyphrases

high fat diet induced
insulin resistance
gene expression
adipose tissue
metabolic syndrome
skeletal muscle
type diabetes
mouse model
wild type