Ursolic acid promotes apoptosis and mediates transcriptional suppression of CT45A2 gene expression in non-small-cell lung carcinoma harbouring EGFR T790M mutations.
Kaiyong YangYan ChenJiaqian ZhouLin MaYating ShanXiaoying ChengYun WangZhaoxin ZhangXiaojun JiLili ChenHui DaiBiqing ZhuChen LiZhonghua TaoXichun HuKaiyong YangPublished in: British journal of pharmacology (2019)
CT45A2 is a novel oncogene for NSCLC with an EGFR T790 mutation. Ursolic acid induced apoptosis and inhibited proliferation of H1975 cells by negatively regulating the β-catenin/TCF4/CT45A2 signalling pathway. Therefore, ursolic acid may be a potential candidate treatment for NSCLC harbouring the EGFR-L858R/T790M mutation.
Keyphrases
- induced apoptosis
- small cell lung cancer
- endoplasmic reticulum stress
- gene expression
- signaling pathway
- oxidative stress
- epidermal growth factor receptor
- image quality
- dual energy
- contrast enhanced
- computed tomography
- tyrosine kinase
- cell cycle arrest
- advanced non small cell lung cancer
- brain metastases
- positron emission tomography
- cell death
- cell proliferation
- magnetic resonance imaging
- stem cells
- pi k akt
- cell therapy
- climate change
- combination therapy
- human health
- bone marrow
- mesenchymal stem cells
- risk assessment
- heat stress
- heat shock protein