Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries.
Ana GomesCátia TeixeiraRicardo FerrazCristina PrudêncioPaula A C GomesPublished in: Molecules (Basel, Switzerland) (2017)
As the incidence of diabetes continues to increase in the western world, the prevalence of chronic wounds related to this condition continues to be a major focus of wound care research. Additionally, over 50% of chronic wounds exhibit signs and symptoms that are consistent with localized bacterial biofilms underlying severe infections that contribute to tissue destruction, delayed wound-healing and other serious complications. Most current biomedical approaches for advanced wound care aim at providing antimicrobial protection to the open wound together with a matrix scaffold (often collagen-based) to boost reestablishment of the skin tissue. Therefore, the present review is focused on the efforts that have been made over the past years to find peptides possessing wound-healing properties, towards the development of new and effective wound care treatments for diabetic foot ulcers and other skin and soft tissue infections.
Keyphrases
- wound healing
- healthcare
- quality improvement
- palliative care
- risk factors
- soft tissue
- type diabetes
- drug induced
- cardiovascular disease
- minimally invasive
- pain management
- affordable care act
- metabolic syndrome
- south africa
- candida albicans
- skeletal muscle
- early onset
- amino acid
- sleep quality
- chronic pain
- combination therapy
- smoking cessation
- adipose tissue