β-Amyloid-Dependent and -Independent Genetic Pathways Regulating CSF Tau Biomarkers in Alzheimer Disease.

Atul KumarShorena JanelidzeErik StomrudSebastian PalmqvistOskar HanssonNiklas Mattsson-Carlgrennull null

Published in: Neurology (2022)

Genetic pathways implicated in causing AD are related to altered levels of soluble tau through both Aβ-dependent and Aβ-independent mechanisms, which may have relevance for anti-tau drug development.

Keyphrases

cerebrospinal fluid
genome wide
copy number
mild cognitive impairment
dna methylation
gene expression