Pd-Catalyzed regio- and stereoselective allylic substitution of vinylethylene carbonates with 1,2,4-triazoles.

N 1 -Substituted 1,2,4-triazoles are ubiquitous skeletons in medicinal agents, agrochemicals, and organic materials. Herein, an efficient and practical method for the synthesis of N 1 -allylated 1,2,4-triazoles via Pd-catalyzed allylic substitution of vinylethylene carbonates (VECs) with 1,2,4-triazoles has been developed. By using a catalyst generated in situ from Pd 2 (dba) 3 ·CHCl 3 and DPPE under mild conditions, the process allows rapid access to N 1 -allylated 1,2,4-triazoles bearing diverse functionalities in high yields with excellent N 1 -selectivities, linear-selectivities, and Z -stereoselectivities.