NLRX1 Prevents M2 Macrophage Polarization and Excessive Renal Fibrosis in Chronic Obstructive Nephropathy.

Ye LiuLotte KorsLoes M ButterGeurt StokmanNike ClaessenCoert J ZuurbierStephen E GirardinJaklien C LeemansSandrine FlorquinAlessandra Tammaro

Published in: Cells (2023)

Our findings highlight the unique role of NLRX1 in regulating the metabolism and function of macrophages, ultimately protecting against excessive renal injury and fibrosis in UUO.

Keyphrases

weight gain
liver fibrosis
body mass index
mouse model
physical activity