Effect of Troxerutin consumption during gestation period on reflexive motor behavior in mice offspring.

This study aimed to determine the effects of Troxerutin consumption during gestation on reflexive motor behavior in mice offspring. Forty pregnant female mice were allocated into four groups. In the control group, mice received water, while in groups 2-4, female mice p.o administered Troxerutin (50, 100, and 150 mg/kg) at 5, 8, 11, 14, and 17 days of gestation (GD). Following delivery, pups were selected based on their experimental group, and reflexive motor behaviors were determined. Also, serum malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GPx) and total antioxidant stsud (TAS) were determined. Based on the findings, maternal exposure to Troxerutin (100 and 150 mg/kg) increased ambulation scores in offispring's compared to control group (P<0.05). Also, prenatal exposure to Troxerutin increased front- and hind-limb suspension scores in new borns compared to control group (P<0.05). Maternal posure to Troxerutin increased grip strength, and negative geotaxis in newborns in comparision to control mice (P<0.05). Prenatal exposure to Troxerutin (100 and 150 mg/kg) decreased hind-limb foot angle and surface righting in pups compared to control group (P<0.05). Maternal exposure to Troxerutin decreased MDA production and increased SOD, GPx, and TAS levels in offspring (P<0.05). These results suggested prenatal consumption of the Troxerutin improves reflexive motor behaviors in mice pups.