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Update on Locoregional Therapies for Cholangiocellular Carcinoma.

Janna MorawitzNils-Martin BruckmannKai JannuschJulian KirchnerGerald AntochSven Heiko LoosenTom LueddeChristoph RoderburgPeter Minko
Published in: Cancers (2023)
Locoregional therapy options for CCA are used, in particular, for non-resectable tumors and aim to reduce tumor viability or delay tumor growth and ultimately prolong overall survival. In addition to local ablative procedures such as radiofrequency- or microwave-ablation, transarterial procedures such as transarterial embolization (TAE), transarterial chemoembolization (TACE), or selective internal radiotherapy (SIRT) play a major role. In particular, in combination with advances in molecular medicine and immunotherapy, there has been a further development in the therapy of primary malignant liver tumors in recent years. In this review, we analyze data from recent studies and examine the implications for therapy of CCA, particularly with regard to the combination of locoregional therapies with modern systemic therapies.
Keyphrases
  • radiofrequency ablation
  • liver metastases
  • locally advanced
  • early stage
  • electronic health record
  • squamous cell carcinoma
  • mesenchymal stem cells
  • smoking cessation
  • artificial intelligence