A novel phosphoproteomic landscape evoked in response to type I interferon in the brain and in glial cells.
Barney ViengkhouMelanie Y WhiteStuart J CordwellIain L CampbellMarkus J HoferPublished in: Journal of neuroinflammation (2021)
Our studies reveal a hitherto unappreciated role for changes in the protein phosphorylation landscape in cellular responses to IFN-I and thus provide insights for novel diagnostic and therapeutic strategies for neurological diseases caused by IFN-I.
Keyphrases
- dendritic cells
- single cell
- induced apoptosis
- immune response
- cell cycle arrest
- cerebral ischemia
- resting state
- white matter
- genome wide
- protein protein
- endoplasmic reticulum stress
- signaling pathway
- amino acid
- case control
- oxidative stress
- cell death
- functional connectivity
- multiple sclerosis
- protein kinase
- pi k akt
- subarachnoid hemorrhage
- blood brain barrier