The dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonist tirzepatide effects on body weight evolution, adiponectin, insulin and leptin levels in the combination of obesity, type 2 diabetes and menopause in mice.
Pedro Henrique Reis-BarbosaIlitch Aquino Marcondes-de-CastroThatiany Souza MarinhoMarcia Barbosa AguilaCarlos Alberto Mandarim-de-LacerdaPublished in: Diabetes, obesity & metabolism (2024)
A model was developed to show three usual factors observed in mature women. Notably, Tzp improved the metabolism and weight loss of OdO mice. Tzp-treated mice showed negative allometric BW across treatment time, which is a quantitative assessment that allows better comparison between results.
Keyphrases
- type diabetes
- high fat diet induced
- weight loss
- insulin resistance
- body weight
- metabolic syndrome
- glycemic control
- bariatric surgery
- polycystic ovary syndrome
- cardiovascular disease
- adipose tissue
- roux en y gastric bypass
- high resolution
- wild type
- gastric bypass
- mass spectrometry
- weight gain
- blood glucose
- physical activity
- pregnancy outcomes
- smoking cessation
- obese patients