Endothelial Histone Deacetylase 1 Activity Impairs Kidney Microvascular NO Signaling in Rats fed a High Salt Diet.
Luke S DunawayAnthony K CookDavide BottaPatrick A MolinaLivius V Dâ UscioZvonimir S KatusicDavid M PollockEdward W InschoJennifer S PollockPublished in: bioRxiv : the preprint server for biology (2023)
We conclude that HS activates endothelial HDAC1 through PDEM leading to decreased NO signaling. This study provides novel insights into the molecular mechanisms by which a HS decreases renal microvascular endothelial NO signaling.