Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing.

Emilie MarhuendaChristine FabreCunjie ZhangMartà Martin-FernandezThomas IskratschAli SalehLuc BauchetJulien CambedouzouJean-Philippe HugnotHugues DuffauJames W DennisDavid CornuNorbert Bakalara

Published in: Journal of experimental & clinical cancer research : CR (2021)

MGAT5 catalysing multibranched N-glycans is a critical regulators of stiffness induced invasion and GSCs mechanotransduction, underpinning MGAT5 as a serious target to treat cancer.

Keyphrases

stem cells
papillary thyroid
high glucose
diabetic rats
squamous cell
cell migration
transcription factor
drug induced
cell therapy
squamous cell carcinoma
young adults