Viewing RCC with a DNA methylation lens ENHANCES understanding of ICI resistance.

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Clear cell renal cell carcinoma tumors with an enhancer demethylator phenotype (TED) harbor a worse prognosis and derive less clinical benefit from immunotherapy. The TED phenotype may help predict immunotherapy resistance.

Keyphrases

dna methylation
gene expression
genome wide
transcription factor
renal cell carcinoma
binding protein
copy number