The maternal reduced uteroplacental perfusion model of preeclampsia induces sexually dimorphic metabolic responses in rat offspring.
Mohammadmehdi Hassanzadeh-TaheriMahtab MohammadifardZahra ErfanianMehran HosseiniPublished in: Biology of sex differences (2022)
The overall results suggest that maternal RUPP has negative and sex-specific impacts on insulin, glucagon and ghrelin regulations in offspring and that, as young adults, male RUPP rats may be more prone to develop obesity and diabetes.
Keyphrases
- type diabetes
- pregnancy outcomes
- young adults
- high fat diet
- birth weight
- glycemic control
- insulin resistance
- weight gain
- metabolic syndrome
- weight loss
- cardiovascular disease
- early onset
- oxidative stress
- adipose tissue
- high fat diet induced
- gestational age
- contrast enhanced
- magnetic resonance
- skeletal muscle
- computed tomography
- body mass index
- childhood cancer