Login / Signup

Trapping of Zwitterionic Intermediates by Isatins and Imines: Synthesis of Benzoxazines Bearing a C4-Quaternary Stereocenter.

Shikun JiaXi YangGuizhi DongChaoqun AoXianxing JiangWenhao Hu
Published in: Organic letters (2019)
Benzoxazines bearing a C4-quaternary stereocenter have been accomplished via the rhodium-catalyzed electrophilic trapping of zwitterionic intermediates by isatins and imines, respectively. The key intermediates of the strategy are proposed to generate from the reaction of donor-acceptor rhodium carbenes with secondary amides. Usage of chiral BINOL-phosphoric acid co-catalyst resulted in enrichment of enantioselectivity in the trapping process with imines.
Keyphrases
  • room temperature
  • ionic liquid
  • highly efficient
  • carbon dioxide
  • mass spectrometry
  • capillary electrophoresis
  • gold nanoparticles
  • energy transfer
  • visible light