Estimating Vitamin K Antagonist Anticoagulation Benefit in People With Atrial Fibrillation Accounting for Competing Risks: Evidence From 12 Randomized Trials.
Sachin J ShahCarl van WalravenSun Young JeonW John BoscardinFrederick David Richard HobbsStuart J ConnollyMichael D EzekowitzKenneth E CovinskyMargaret C FangDaniel E SingerPublished in: Circulation. Cardiovascular quality and outcomes (2024)
-VASc, which does not account for the competing risk of death nor decelerating treatment benefit over time. Overestimation was most pronounced when life expectancy was low and when the benefit was estimated over a multiyear horizon.