Downregulation of Claudin5 promotes malignant progression and radioresistance through Beclin1-mediated autophagy in esophageal squamous cell carcinoma.

Shan HuangJiayi ZhangYi LiYaqiong XuHui JiaLei AnXiaotan WangYuting Yang

Published in: Journal of translational medicine (2023)

In summary, these findings suggest that downregulation of Claudin5 promotes ESCC malignant progression and radioresistance via Beclin1-autophagy activation and may serve as a promising biomarker for predicting radiotherapy response and patient outcome in ESCC.

Keyphrases

signaling pathway
cell death
endoplasmic reticulum stress
cell proliferation
oxidative stress
early stage
dna damage response
radiation therapy
case report
radiation induced
cancer stem cells
squamous cell carcinoma
dna repair