Obesogenic Diet in Mice Leads to Inflammation and Oxidative Stress in the Mother in Association with Sex-Specific Changes in Fetal Development, Inflammatory Markers and Placental Transcriptome.
Alejandro A CandiaSamantha C LeanCindy X W ZhangDaniel R McKeatingAnna CochraneEdina GulacsiEmilio A HerreraBernardo J KrauseAmanda Nancy Sferruzzi-PerriPublished in: Antioxidants (Basel, Switzerland) (2024)
This study shows that fetal growth restriction with maternal obesity is related to elevated oxidative stress, inflammatory pathways, and sex-specific placental changes. Our data are important, given the marked consequences and the rising rates of obesity worldwide.
Keyphrases
- oxidative stress
- high fat diet induced
- weight loss
- insulin resistance
- metabolic syndrome
- weight gain
- diabetic rats
- dna damage
- ischemia reperfusion injury
- type diabetes
- induced apoptosis
- birth weight
- physical activity
- electronic health record
- gene expression
- rna seq
- single cell
- adipose tissue
- body mass index
- machine learning
- pregnancy outcomes
- heat stress
- gestational age