SUMOylation of nuclear receptor Nor1/NR4A3 coordinates microtubule cytoskeletal dynamics and stability in neuronal cells.

Jonathan GagnonVéronique CaronAndré Tremblay

Published in: Cell & bioscience (2024)

Our study provides novel insights into Nor1 transcriptional signaling competence and identifies a hierarchical mechanism whereby selective Nor1 SUMOylation may govern neuronal cytoskeleton network dynamics and resistance against microtubule disturbances, a condition strongly associated with neurodegenerative diseases.

Keyphrases

blood brain barrier
induced apoptosis
cell cycle arrest
gene expression
oxidative stress
endoplasmic reticulum stress
cell death
heat shock
subarachnoid hemorrhage
network analysis