The Effect of Sodium-Glucose Cotransporter Inhibitors on Renal Function as Adjunctive to Insulin in Adults with Type 1 Diabetes: An Updated Multilevel Meta-analysis of Randomized Controlled Trials.
Paschalis KarakasisDjordje S PopovicDimitrios PatouliasTheocharis KoufakisNikolaos PapanasNikolaos FragakisManfredi RizzoPublished in: Diabetes therapy : research, treatment and education of diabetes and related disorders (2024)
Our findings suggest that adjunctive therapy with SGLT inhibitors results in a significant reduction in albuminuria, while their use is associated with a neutral effect on creatinine clearance, as a measure of renal function. Future renal outcome trials are needed to assess SGLT inhibitors' role in the pharmacological armamentarium against diabetic nephropathy in T1D.