Back to the Future: Is GnRHa Treatment in Transgender and Gender Diverse Adolescents Only an Extended Evaluation Phase?

Alessandra Daphne FisherJiska RistoriAlessia RomaniEmanuele CassioliFrancesca MazzoliCarlotta CocchettiMarina PierdominiciMatteo MarconiValdo RiccaMario MaggiLinda VignozziGiovanni Castellini

Published in: The Journal of clinical endocrinology and metabolism (2024)

Psychological improvement in TGDA on GnRHa seems to be related to the objective body changes induced by a GnRHa. Therefore, the rationale for treatment with a GnRHa may not only be considered an extension of the evaluation phase, but also the start of a medical (even if reversible) gender-affirming path, especially in TGDAs whose puberty has already progressed.

Keyphrases

young adults
mental health
physical activity
clinical trial
combination therapy
depressive symptoms
replacement therapy
hiv infected