Severe skin toxicity during whole-brain radiotherapy, targeted therapy, and additional drug intake including St. John's wort skin oil.
Tanja EichkornFabian SchunnSebastian RegneryRami El ShafieJuliane Hörner-RieberSebastian AdebergKlaus HerfarthJürgen DebusLaila KönigPublished in: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (2021)
St. John's wort seems to be a significant radiosensitizer for photon radiotherapy and can cause severe skin toxicity even though the literature lacks data on this interaction. As an OTC, it is easily accessible and often used by oncological patients due to antidepressant and local antimicrobial and pain-relieving effects.
Keyphrases
- soft tissue
- end stage renal disease
- early stage
- wound healing
- chronic kidney disease
- oxidative stress
- ejection fraction
- newly diagnosed
- locally advanced
- early onset
- systematic review
- chronic pain
- peritoneal dialysis
- staphylococcus aureus
- major depressive disorder
- squamous cell carcinoma
- machine learning
- prostate cancer
- emergency department
- white matter
- multiple sclerosis
- radical prostatectomy
- resting state
- spinal cord injury
- blood brain barrier
- spinal cord
- big data
- living cells
- brain injury