Effects of Huazhuo Jiedu Shugan Decoction on Cognitive and Emotional Disorders in a Rat Model of Epilepsy: Possible Involvement of AC-cAMP-CREB Signaling and NPY Expression.

Xin PingShao-Kun QinShu-Ning LiuYe LuYa-Nan ZhaoYa-Fei CaoYan-Hong ZhangShao-Dan Zhang Li Chu Lin Pei

Published in: Evidence-based complementary and alternative medicine : eCAM (2019)

The current results demonstrate that HJSD treatment in epileptic rats markedly inhibits epileptic seizures and improves cognitive and emotional disorders, which may be related to the regulation of AC-cAMP-CREB signaling and NPY expression in the hippocampus. The effects of the HJSD treatment may provide a foundation for the use of HJSD as a prescription medicinal herb in the TCM for the treatment of epilepsy.

Keyphrases

combination therapy
long non coding rna
subarachnoid hemorrhage
protein kinase
drug induced
cerebral ischemia