PANoptosis: Mechanism and Role in Pulmonary Diseases.
Shiyi ChenJiacheng JiangTongfu LiLong Shuang HuangPublished in: International journal of molecular sciences (2023)
PANoptosis is a newly defined programmed cell death (PCD) triggered by a series of stimuli, and it engages three well-learned PCD forms (pyroptosis, apoptosis, necroptosis) concomitantly. Normally, cell death is recognized as a strategy to eliminate unnecessary cells, inhibit the proliferation of invaded pathogens and maintain homeostasis; however, vigorous cell death can cause excessive inflammation and tissue damage. Acute lung injury (ALI) and chronic obstructive pulmonary syndrome (COPD) exacerbation is related to several pathogens (e.g., influenza A virus, SARS-CoV-2) known to cause PANoptosis. An understanding of the mechanism and specific regulators may help to address the pathological systems of these diseases. This review presents our understanding of the potential mechanism of PANoptosis and the role of PANoptosis in different pulmonary diseases.
Keyphrases
- cell death
- cell cycle arrest
- pulmonary hypertension
- sars cov
- oxidative stress
- chronic obstructive pulmonary disease
- induced apoptosis
- pi k akt
- gram negative
- signaling pathway
- lipopolysaccharide induced
- physical activity
- antimicrobial resistance
- endoplasmic reticulum stress
- transcription factor
- lung function
- lps induced
- multidrug resistant
- intensive care unit
- cystic fibrosis
- case report
- risk assessment
- inflammatory response
- cell proliferation
- respiratory syndrome coronavirus