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Silica nanoparticles induce neurodegeneration-like changes in behavior, neuropathology, and affect synapse through MAPK activation.

Ran YouYuen-Shan HoClara Hiu-Ling HungYan LiuChun-Xia HuangHei-Nga ChanSee-Lok HoSheung-Yeung LuiHung-Wing LiRaymond Chuen-Chung Chang
Published in: Particle and fibre toxicology (2018)
Intranasal instillation of SiO2-NPs results in mood dysfunction and cognitive impairment in young adult mice and causes neurodegeneration-like pathology and synaptic changes via ERK activation.
Keyphrases
  • cognitive impairment
  • signaling pathway
  • young adults
  • oxidative stress
  • pi k akt
  • cell proliferation
  • high fat diet induced
  • metabolic syndrome
  • physical activity
  • childhood cancer