Silica nanoparticles induce neurodegeneration-like changes in behavior, neuropathology, and affect synapse through MAPK activation.

Ran YouYuen-Shan HoClara Hiu-Ling HungYan LiuChun-Xia HuangHei-Nga ChanSee-Lok HoSheung-Yeung LuiHung-Wing LiRaymond Chuen-Chung Chang

Published in: Particle and fibre toxicology (2018)

Intranasal instillation of SiO2-NPs results in mood dysfunction and cognitive impairment in young adult mice and causes neurodegeneration-like pathology and synaptic changes via ERK activation.

Keyphrases

cognitive impairment
signaling pathway
young adults
oxidative stress
pi k akt
cell proliferation
high fat diet induced
metabolic syndrome
physical activity
childhood cancer