Silica nanoparticles induce neurodegeneration-like changes in behavior, neuropathology, and affect synapse through MAPK activation.
Ran YouYuen-Shan HoClara Hiu-Ling HungYan LiuChun-Xia HuangHei-Nga ChanSee-Lok HoSheung-Yeung LuiHung-Wing LiRaymond Chuen-Chung ChangPublished in: Particle and fibre toxicology (2018)
Intranasal instillation of SiO2-NPs results in mood dysfunction and cognitive impairment in young adult mice and causes neurodegeneration-like pathology and synaptic changes via ERK activation.