Association of Hyperferritinemia With Distinct Host Response Aberrations in Patients With Community-Acquired Pneumonia.

Xanthe BrandsTjitske S R van EngelenFloris M C de VriesBastiaan W HaakAugustijn M KlarenbeekMaadrika M N P KanglieInge A H van den BerkAlex R SchuurmanHessel Peters-SengersNatasja A OttoDaniël R FaberRené LutterBrendon P SciclunaJaap StokerJan M PrinsW Joost WiersingaTom van der Poll

Published in: The Journal of infectious diseases (2022)

Hyperferritinemia identifies patients with CAP with a broad deregulation of various host response mechanisms implicated in the pathogenesis of sepsis. This could inform future therapeutic strategies targeting subgroups within the CAP population.

Keyphrases

community acquired pneumonia
intensive care unit
acute kidney injury
genome wide
cancer therapy
current status
copy number
septic shock
gene expression
drug delivery