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Establishing Communication Between Artificial Cells.

Lukas AufingerFriedrich C Simmel
Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2019)
Communication between artificial cells is essential for the realization of complex dynamical behaviors at the multi-cell level. It is also an important prerequisite for modular systems design, because it determines how spatially separated functional modules can coordinate their actions. Among others, molecular communication is required for artificial cell signaling, synchronization of cellular behaviors, computation, group-level decision-making processes and pattern formation in artificial tissues. In this review, an overview of various recent approaches to create communicating artificial cellular systems is provided. In this context, important physicochemical boundary conditions that have to be considered for the design of the communicating cells are also described, and a survey of the most striking emergent behaviors that may be achieved in such systems is given.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • decision making
  • endoplasmic reticulum stress
  • gene expression
  • cell death
  • stem cells
  • signaling pathway
  • bone marrow
  • mesenchymal stem cells
  • pi k akt
  • density functional theory