Younger Age and Parenchyma-Sparing Surgery Positively Affected Long-Term Health-Related Quality of Life after Surgery for Pancreatic Neuroendocrine Neoplasms.
Anna Caterina MilanettoClaudia ArmellinGloria BrigiariGiulia LorenzoniClaudio PasqualiPublished in: Journal of clinical medicine (2023)
(1) Background: Patients with pancreatic Neuroendocrine Neoplasms (PanNENs) often have a long overall survival. We evaluated determinants of quality of life (QoL) after surgery for PanNENs. (2) Methods: Patients operated on for a PanNEN in our center (1990-2021) received three EORTC QoL questionnaires (QLQ-C30, QLQ-GI.NET21, QLQ-PAN26). Six domains were selected as outcome variables (global QoL, physical function -PF, social function -SF, disease-related worries -DRWs, pain, upper-gastrointestinal (GI) symptoms) and evaluated in relation to the clinical variables. Statistical analysis was performed using R software v 4.2.2. (3) Results: One hundred and four patients enrolled showed a good global QoL (median 83.3). Old age was a determinant of worse global QoL ( p 0.006) and worse PF ( p 0.003). Multiple comorbidities ( p 0.002) and old age ( p 0.034) were associated with pain, while male gender was related to better PF ( p 0.007) and less pain ( p 0.012). Patients who had undergone parenchyma-sparing surgery demonstrated better PF ( p 0.037), better SF ( p 0.012), and less upper-GI symptoms ( p 0.047). At multivariable analysis, age ( p 0.005) and type of surgery ( p 0.028) were confirmed as determinants of global QoL. (4) Conclusions: In patients operated on for a PanNEN, a good HRQoL is generally reported; notably, younger age and parenchyma-sparing surgery seem to positively affect HRQoL.
Keyphrases
- end stage renal disease
- minimally invasive
- ejection fraction
- chronic kidney disease
- newly diagnosed
- coronary artery bypass
- chronic pain
- peritoneal dialysis
- prognostic factors
- pain management
- mental health
- spinal cord injury
- spinal cord
- depressive symptoms
- acute coronary syndrome
- physical activity
- atrial fibrillation
- sleep quality
- patient reported outcomes