Swertiamarin mitigates nephropathy in high-fat diet/streptozotocin-induced diabetic rats by inhibiting the formation of advanced glycation end products.
Kirti ParwaniFarhin PatelPranav BhagwatHaritha DilipDhara PatelVijay ThiruvenkatamPalash MandalPublished in: Archives of physiology and biochemistry (2021)
SM ameliorated DN by inhibiting the oxidative stress induced by AGEs.HighlightsSM reduces the levels of hyperglycaemia-induced advanced glycation end products in serum and renal tissue.SM prevents renal fibrosis by inhibiting the EMT in the kidney tissue.The in-silico analysis proves that SM can inhibit the binding of various AGEs with RAGE, thereby inhibiting the AGE-RAGE axis.
Keyphrases
- diabetic rats
- oxidative stress
- high fat diet
- signaling pathway
- adipose tissue
- insulin resistance
- dna damage
- ischemia reperfusion injury
- epithelial mesenchymal transition
- induced apoptosis
- type diabetes
- molecular docking
- mouse model
- radiation therapy
- transcription factor
- radiation induced
- heat stress
- heat shock
- dna binding
- data analysis