Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene transcription.

Debora SalernoLetizia Chiodo Vincenzo AlfanoOceane FloriotGrazia CottoneAlexia PaturelMatteo PalloccaMarie-Laure PlissonnierSafaa JeddariLaura BelloniMirjam ZeiselMassimo Levrero Francesca Guerrieri

Published in: Gut (2020)

Our results highlight the ability of HBx to bind RNA to impact on the epigenetic control of both viral cccDNA and host genes and provide a new key to understand the role of DLEU2 and EZH2 overexpression in HBV-related HCCs and HBx contribution to hepatocytes transformation.

Keyphrases

hepatitis b virus
genome wide
genome wide identification
transcription factor
dna methylation
long non coding rna
liver failure
long noncoding rna
sars cov
gene expression
cell proliferation
copy number
protein protein
binding protein
amino acid
bioinformatics analysis