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The Prognostic Hub Gene POLE2 Promotes BLCA Cell Growth via the PI3K/AKT Signaling Pathway.

Dongzhen JiangHuawei ZhangBingde YinMinke HeXuwei LuChang He
Published in: Combinatorial chemistry & high throughput screening (2024)
In conclusion, POLE2 was identified to be a promising prognostic biomarker as an oncogene in BLCA. It was also found that POLE2 exerts a promoting function by the PI3K/AKT signaling pathway in BLCA.
Keyphrases
  • signaling pathway
  • pi k akt
  • epithelial mesenchymal transition
  • induced apoptosis
  • genome wide
  • copy number
  • gene expression
  • dna methylation
  • oxidative stress
  • genome wide identification