Regium-π Bonds Are Involved in Protein-Gold Binding.

María de Las Nieves PiñaAntonio Frontera Antonio Bauzá

Published in: The journal of physical chemistry letters (2020)

The regium-π interaction is an attractive noncovalent force between group 11 elements (Cu, Ag, and Au) acting as Lewis acids and aromatic surfaces. Herein, we report for the first time experimental (Protein Data Bank analysis) and theoretical (RI-MP2/def2-TZVP level of theory) evidence of regium-π bonds involving Au(I) and aromatic amino acids (Phe, Tyr, Trp, and His). These findings might be important in the field of drug design and for retrospectively understanding the role of gold in proteins.

Keyphrases

amino acid
sensitive detection
binding protein
reduced graphene oxide
protein protein
electronic health record
visible light
silver nanoparticles
quantum dots
emergency department
single molecule
escherichia coli
machine learning
small molecule
cystic fibrosis
dna binding
drug induced