Mendelian randomization study on causal association of IL-6 signaling with pulmonary arterial hypertension.
Min ZhangQi ZengShan ZhouGaizhi ZhuYaqi XuRan GaoWenting SuRenxi WangPublished in: Clinical and experimental hypertension (New York, N.Y. : 1993) (2023)
Our analysis suggested the causal link between genetically increased sIL-6 R and increased risk of PAH and between genetically increased IL-6 signaling and reduced risk of PAH. Thus, higher sIL-6 R levels may be a risk factor for patients with PAH, whereas higher IL-6 signaling may be a protective factor for patients with PAH.