Secondary Neoplasms After Hematopoietic Cell Transplant for Sickle Cell Disease.
Mary EapenRuta BrazaukasDavid A WilliamsMark C WaltersAndrew St MartinBenjamin L JacobsJoseph H AntinKira O BonaSonali ChaudhuryVictoria H Coleman-CowgerNancy L DiFronzoErica B EsrickJoshua J FieldCourtney D FitzhughJulie KanterNeena KapoorDonald B KohnLakshmanan KrishnamurtiWendy B LondonMichael A PulsipherSohel TalibAlexis A ThompsonEdmund K WallerTed WunMary M HorowitzPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
Low-intensity regimens rely on tolerance induction and establishment of mixed-donor chimerism. Persistence of host cells exposed to low-dose radiation triggering myeloid malignancy is one plausible etiology. Pre-existing myeloid mutations and prior inflammation may also contribute but could not be studied using our data source. Choosing conditioning regimens likely to result in full-donor chimerism may in part mitigate the higher risk for leukemia/MDS.
Keyphrases
- sickle cell disease
- bone marrow
- acute myeloid leukemia
- low dose
- allogeneic hematopoietic stem cell transplantation
- induced apoptosis
- dendritic cells
- oxidative stress
- single cell
- cell cycle arrest
- high dose
- mesenchymal stem cells
- big data
- endoplasmic reticulum stress
- signaling pathway
- stem cells
- radiation therapy
- cell death
- acute lymphoblastic leukemia
- data analysis
- cell proliferation
- solid state