Identification of extracellular vesicle microRNA signatures specifically linked to inflammatory and metabolic mechanisms in obesity-associated low type-2 asthma.
Fahd AlhamdanTimm GreulichChristian DaviaudLeigh Matthew MarshFrauke PedersenClemens ThölkenPetra Ina PfefferleThomas BahmerDaniel P PotaczekJorg TostHolger GarnPublished in: Allergy (2023)
The identified plasma EV miRNA signatures and particularly the miR-17-92 and -106a-363 clusters were capable to disentangle specific mechanisms of the obesity-associated low type-2 asthma phenotype, which may serve as basis for stratified treatment development.
Keyphrases
- insulin resistance
- metabolic syndrome
- chronic obstructive pulmonary disease
- weight loss
- lung function
- type diabetes
- high fat diet induced
- weight gain
- cell proliferation
- genome wide
- allergic rhinitis
- long non coding rna
- oxidative stress
- adipose tissue
- gene expression
- body mass index
- combination therapy
- smoking cessation