Epigenetic and non-epigenetic mode of SIRT1 action during oocyte meiosis progression.
Jan NevoralLukas LandsmannMiriam StiavnickaPetr HosekJiri MoravecSarka ProkesovaHedvika RimnacovaEliska KoutnaPavel KleinKristyna HoskovaTereza ZalmanovaTereza FenclovaJaroslav PetrMilena KralickovaPublished in: Journal of animal science and biotechnology (2019)
Taken together, our observations point out the dual spatiotemporal SIRT1 action in oocytes, which can be readily switched from the epigenetic to non-epigenetic mode of action depending on the progress of meiosis.