Genome-wide analysis of carotid plaque burden suggests a role of IL5 in men.

Janne PottFrank BeutnerKatrin HornHolger KirstenKay OlischerKerstin WirknerMarkus LoefflerMarkus Scholz

Published in: PloS one (2020)

We showed that CPB is a complementary trait in analyzing genetics of subclinical atherosclerosis. We detected a novel locus for plaque size in men only suggesting a role of IL5. Several estrogen response elements in this locus point towards a functional explanation of the observed sex-specific effect.

Keyphrases

genome wide analysis
coronary artery disease
middle aged
genome wide association study
cardiovascular disease
genome wide
estrogen receptor