Serum Levels of BDNF in Cardiovascular Protection and in Response to Exercise.
Ivani Credidio TrombettaJosé Roberto DeMouraCleber Rene AlvesRenato Carbonari-BritoFelipe Xerez CepedaJosé Ribeiro LemosPublished in: Arquivos brasileiros de cardiologia (2020)
Cardiovascular disease (CVD) is currently the leading cause of death in Brazil and worldwide. In 2016, CVD accounted for more than 17 million deaths, representing 31% of all deaths globally. Molecular and genetic mechanisms may be involved in vascular protection and should be considered in new therapeutic approaches. In this sense, recent studies have reported that brain-derived neurotrophic factor (BDNF) is reduced in individuals predisposed to develop CVD, and that aerobic physical training increases the amounts of circulating BDNF. BDNF is a neurotrophin found at high concentrations in the hippocampus and cerebral cortex and is considered a key molecule for the maintenance of synaptic plasticity and survival of neuronal cells. In addition to neuronal plasticity, BDNF is also important in vascular function, promoting angiogenesis through the regulation of reactive oxygen species (ROS). However, a variant of the BDNF gene in humans, the Val66Met polymorphism (substitution of the amino acid valine for a methionine at position 66 of the codon), occurring in 20-30% of the Caucasian population, may affect plasma BDNF concentrations and its activity in all peripheral tissues containing tyrosine kinase B receptors (TrkB), such as the endothelium. Thus, we will present a discussion about the role of serum BDNF levels in cardiovascular protection, Val66Met genetic variant in vascular reactivity and the effect of physical exercise.
Keyphrases
- tyrosine kinase
- stress induced
- cardiovascular disease
- reactive oxygen species
- physical activity
- genome wide
- copy number
- type diabetes
- high intensity
- gene expression
- epidermal growth factor receptor
- induced apoptosis
- cerebral ischemia
- dna damage
- endothelial cells
- coronary artery disease
- brain injury
- oxidative stress
- metabolic syndrome
- functional connectivity
- dna methylation
- vascular endothelial growth factor
- cardiovascular events
- free survival
- single molecule
- cerebral blood flow