Inhibition of Autophagy Facilitates XY03-EA-Mediated Neuroprotection against the Cerebral Ischemia/Reperfusion Injury in Rats.

Wen-Wen Cui Yuan-Yuan Hao Ming-Ye Wang Qiuyan Zhang Junmei Wang Gang Wei Yun-Long Hou

Published in: Oxidative medicine and cellular longevity (2022)

In this study, we found that XY03-EA alleviated the cerebral I/R injuries in rats and nonhuman primates. Our results demonstrated that XY03-EA exerted neuroprotective effects against the ROS-mediated autophagic neurocyte death and had great potential for the treatment of ischemic stroke.

Keyphrases

cell death
subarachnoid hemorrhage
cerebral ischemia
brain injury
oxidative stress
dna damage
signaling pathway
atrial fibrillation
blood brain barrier
reactive oxygen species
climate change
risk assessment
replacement therapy