Exposure-Response Relationship of Posaconazole Suspension in Theprophylaxis of Invasive Fungal Infections in Patients with Acute Myeloid Leukemia.

Manju SengarHasmukh JainSanyo D'souzaSadhana KannanSmruti MokalMurari GurjarMadhavi AmbotkarNeha SharmaMounika BoppannaVikram Gota

Published in: Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion (2022)

A significant proportion of patients receiving posaconazole prophylaxis fail to achieve target plasma levels which can result in high risk of development of IFI. Occurrence of diarrhea, vomiting and mucositis can adversely affect the achievement target plasma levels.

Keyphrases

acute myeloid leukemia
chemotherapy induced
risk assessment
radiation induced
allogeneic hematopoietic stem cell transplantation
irritable bowel syndrome
acute lymphoblastic leukemia
abdominal pain