Lymphocytic Colitis With Increased Apoptosis: A Marker of Mutation in T-Cell-Mediated Immunity?
Anas BerniehMelanie HakarJerzy StanekPublished in: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society (2020)
Lymphocytic colitis is a subtype of microscopic colitis that is mostly seen in adults. It presents mainly as chronic nonbloody diarrhea, with the hallmark of normal or near-normal endoscopy. In this case series, we are presenting 4 pediatric patients with lymphocytic colitis with prominent apoptosis of the colonic gland epithelium. Remarkably, all the patients have genetic mutations known to be associated with autoimmune enteropathy. Three patients have a CTLA4 mutation, and 1 patient has an STAT3 mutation. These mutations were previously reported in association with inflammatory bowel disease, but a specific connection with lymphocytic colitis has not been described. This report investigates the histopathology of such lesions in children and adolescents.
Keyphrases
- end stage renal disease
- ulcerative colitis
- ejection fraction
- newly diagnosed
- chronic kidney disease
- oxidative stress
- prognostic factors
- endoplasmic reticulum stress
- cell death
- cell proliferation
- multiple sclerosis
- gene expression
- cell cycle arrest
- signaling pathway
- dna methylation
- drug induced
- small bowel
- patient reported