Population pharmacokinetics of cefuroxime and uptake into hip and spine bone of patients undergoing orthopaedic surgery.
Ulrich GergsLina BeckerRichard OkoniewskiMichael WeissKarl-Stefan DelankJoachim NeumannPublished in: The Journal of pharmacy and pharmacology (2019)
Even if a majority of patients undergoing hip or spine surgery probably achieved adequate concentrations of cefuroxime, not all patients reached bone concentrations of cefuroxime above a recommended breakpoint for susceptible germs at the time of surgery.